The study of the autonomic nervous system (ANS) function has shown to provide useful indicators for risk stratification and early detection on a variety of cardiovascular pathologies. However, data gathered during different tests of the ANS are difficult to analyse, mainly due to the complex mechanisms involved in the autonomic regulation of the cardiovascular system (CVS). Although model-based analysis of ANS data has been already proposed as a way to cope with this complexity, only a few models coupling the main (...) elements involved have been presented in the literature. In this paper, a new model of the CVS, representing the ventricles, the circulatory system and the regulation of the CVS activity by the ANS, is presented. The models of the vascular system and the ventricular activity have been developed using the Bond Graph formalism, as it proposes a unified representation for all energetic domains, facilitating the integration of mechanic and hydraulic phenomena. In order to take into account the electro-mechanical behaviour of both ventricles, an electrophysiologic model of the cardiac action potential, represented by a set of ordinary differential equations, has been integrated. The short-term ANS regulation of heart rate, cardiac contractility and peripheral vasoconstriction is represented by means of continuous transfer functions. These models, represented in different continuous formalisms, are coupled by using a multi-formalism simulation library. Results are presented for two different autonomic tests, namely the Tilt Test and the Valsalva Manoeuvre, by comparing real and simulated signals. (shrink)

Recall that B is PA relative to A if B computes a member of every nonempty $\Pi ^0_1(A)$ class. This two-place relation is invariant under Turing equivalence and so can be thought of as a binary relation on Turing degrees. Miller and Soskova [23] introduced the notion of a $\Pi ^0_1$ class relative to an enumeration oracle A, which they called a $\Pi ^0_1{\left \langle {A}\right \rangle }$ class. We study the induced extension of the relation B is PA relative (...) to A to enumeration oracles and hence enumeration degrees. We isolate several classes of enumeration degrees based on their behavior with respect to this relation: the PA bounded degrees, the degrees that have a universal class, the low for PA degrees, and the ${\left \langle {\text {self}\kern1pt}\right \rangle }$ -PA degrees. We study the relationship between these classes and other known classes of enumeration degrees. We also investigate a group of classes of enumeration degrees that were introduced by Kalimullin and Puzarenko [14] based on properties that are commonly studied in descriptive set theory. As part of this investigation, we give characterizations of three of their classes in terms of a special sub-collection of relativized $\Pi ^0_1$ classes—the separating classes. These three can then be seen to be direct analogues of three of our classes. We completely determine the relative position of all classes in question. (shrink)

Résumé Cet article offre une nouvelle lecture et interprétation des premières lignes préservées du décret issu par la cité éolique d’Aigai en l’honneur du roi Séleucos I et de son fils Antiochos, à la suite de la bataille de Kouroupédion. Le commentaire se focalise sur le rapport entre la syntaxe et le message du texte, sur l’utilisation de la dénomination sôteres, entre nom commun et épiclèse cultuelle, ainsi que sur la manière de laquelle les citoyens d’Aigai ont justifié l’octroi des (...) plus grands honneurs cultuels, par lesquels leurs bienfaiteurs sont adressés en qualité de divinités qui se sont manifestées. (shrink)

RésuméCette étude retrace l'évolution des recherches de von Wright en logique déontique depuis 1951 jusqu'à la fin des années 70. J'ai préféré, à une suite d'exposés isolés et indépendants à propos de chaque système, m'attacher à la mise en évidence des différences et des similitudes; je montre en quoi chaque étape est originale. Je reléve d'abord les traits saillants du système de 1951 et ceux de la construction de 1963, après avoir analysé les raisons du passage du premier à la (...) seconde. Ensuite, j'expose le profil essentiel de la généralisation métalogique de 1968. Enfin, je décris les tentatives de réduction de la logique déontique à des logiques plus familieres et j'examine à propos de positions très recentes ce qui va dans le sens de la reprise de l'ancien et ce qui marque des ruptures radicales avec tout ce qui précéde.SummaryThis study describes the evolution of von Wright's investigations about deontic logic from 1951 until the late 70. Rather than isolated expositions of a series of independent systems, I prefered to attach myself to differences and similitudes. I strived to show the originality of each conception. First, I call attention to the 1951 system principal features; I analyse the reasons which compelled von Wright to construct the 1963 logico‐philosophical system. Then I describe the essential profile of the 1968 metalogic generalisation. So, I come to the reductionnist tentations, concluding with the examination of very recent positions. In the conceptions of the late 70, we find a lot of things which repeat the past, but also extreme originality on many points. (shrink)

IPCC SPECIAL REPORT ON CLIMATE CHANGE AND LAND (SRCCL) -/- Chapter 3: Climate Change and Land: An IPCC special report on climate change, desertification, land degradation, sustainable land management, food security, and greenhouse gas fluxes in terrestrial ecosystems.

Introduction -- Part I. Constructing a framework for critical comparison. Introducing Jung and Balthasar -- A framework for critical comparison -- -- Part II. Bases for critical comparison. Anthropology and theological orientation -- Analogy and polarity -- -- Part III. God's involvement with evil. Evil - its origins and reality -- Jung on God's involvement with evil -- The Cross in Jung and Balthasar -- -- Part IV. Conclusion. A cruciform model for God's involvement with evil -- Summary.

Fenomen russkogo kosmizma -- Nikolaĭ Fedorovich Fedorov -- Konstantin Ėduardovich T︠S︡iolkovskiĭ -- Vladimir Ivanovich Vernadskiĭ -- Aleksandr Leonidovich Chizhevskiĭ.

Ce texte répond aux critiques formulées par J.G. Hülsmann à propos de mon article “Ludwig von Mises, Théoricien de la Banque Libre”. J.G. Hülsmann me reproche une méthode scientifique douteuse sans voir que ses reproches ne s’adressent qu’à luimême. Pour lui répondre, il me suffit de le paraphraser. Le commentaire de Hülsmann a néanmoins un léger mérite, celui de mettre en exergue deux courts passages de l’oeuvre de Mises que j’omets involontairement dans mon article. Aussi il me revient de combler (...) cette lacune, d’interpréter ces deux passages, d’affiner et finalement d’appuyer le propos et la conclusion de mon article.This article is a reply to J.G. Hülsmann’s critics concerning my article “Ludwig von Mises, Théoricien de la Banque Libre”. J.G. Hülsmann blames me for an uncertain scientific method when these reproaches are aimed at himself. To respond, we just have to paraphrase. Nevertheless, for the credit of Hülsmann’s commentary, we have to say that it makes appear two short citations of Mises’ work that we unintentionally ignore in our article. So, to fill the gap, I have to interpret these citations, improve and finally rest the purpose and the conclusion of my article. (shrink)

La question de fond traitée dans cet article est celle des rapports entre la science et la philosophie. Cette question est abordée par le biais d'une considération de la critique de la science élaborée par la phénoménologie. La philosophie de Merleau-Ponty sert d'exemple de la position phénoménologique. Le but de l'article est de démontrer l'insuffisance de la position de Merleau-Ponty — et, par extension, de la phénoménologie en général — en ce qui concerne son appréciation de la nature véritable du (...) projet scientifique. A cette fin, on essaie de saisir le sens véritable des développements récents dans la science en examinant quatre cas particuliers : la physique nucléaire, la psychologie, la biologie moléculaire, la cybernétique. Le résultat de cette analyse est de montrer que la lecture que faisait Merleau-Ponty des visées et des tendances de la science était erronée et que la position classique de la phénoménologie est indéfendable. Comme, cependant, l'auteur se trouve en accord avec la motivation profonde de Merleau-Ponty et de la phénoménologie en ce qui concerne l'irréductibilité du sujet ou de la conscience à l'objectivisme scientifique, il est alors amené à se demander ce que pourrait être une position phénoménologique satisfaisante vis-à-vis de la science. C'est ainsi que l'article se termine par une critique de toute position positiviste en philosophie et par une tentative d'indiquer ce que devrait être la véritable nature du discours philosophique, une fois que celui-ci est purifié de tout empirisme, c'est-à-dire de toute prétention à des connaissances positives.The basic question delt with in this article is that of the relation between science and philosophy. This question is approached through a consideration of the phenomenological critique of science. The philosophy of Merleau-Ponty is taken as an example of the phenomenological position. The aim of the article is to show the insufficiency of Merleau-Ponty's position — and, by implication, of phenomenology in general — as regards his estimation of the true nature of the scientific project. To this end an attempt is made to seize hold of the true meaning of recent developments in science by examining four special instances : nuclear physics, psychology, molecular biology, cybernetics. The result of this analysis is to show that Merleau-Ponty's interpretation of aims and tendencies of science was mistaken and that the position normally taken by phenomenology cannot be defended. As, however, the author is in agreement with the basic motivation of Merleau-Ponty and of phenomenology as regard the irreducibility of the subject or consciousness to scientific objectivism, he is thus led to ask what might be a satisfactory phenomenological position vis-a-is science. The article thus ends a critique of all positivist positions in philosophy and with an attempt to indicate what must be the true nature of philosophical discourse, once this has been purified of all empirical elements, i.e., of all claims to positive knowledge. (shrink)

In their environment, plants are continuously submitted to natural stimuli such as wind, rain, temperature changes, wounding, etc. These signals induce a cascade of events which lead to metabolic and morphogenetic responses. In this paper the different steps are described and discussed starting from the reception of the signal by a plant organ to the final morphogenetic response. In our laboratory two plants are studied: Bryonia dioica for which rubbing the internode results in reduced elongation and enhanced radial expansion and (...) Bidens pilosa for which the response occurs at distance, hence pricking the cotyledon of a plantlet induces the growth inhibition of both the hypocotyl and the axillary bud of the pricked cotyledon. Reception of the signal and transmission of the message. In Bryonia the signal is received by epidermal cells while in Bidens they are the cells adjacent to the midrib of the cotyledon which receive the mechanical signal. In both plants the message is transmitted via a wave of electric depolarization. This latter is composed of an action potential associated with a slow wave whose transmission rates are respectively 1cm s−1 and 1 mm s−1. Recent results have shown the involvement of Ca2+ in the triggering of the slow wave and the role of the H+ pump during the slow wave. Transient and fast biochemical responses. An entry of extraceilular Ca2+ into the cells and a transient increase in IP3 occur within seconds following the mechanical stimulus. At the same time, the membrane becomes more fluid, correlated with qualitative changes in phospholipids. The rapid increase in the concentration of peroxidated lipids may be correlated with ethylene biosynthesis which is stimulated after rubbing. Other parameters such as cytoplasmic pH, relative water content, hydric potential, membrane potential and modifications of K+, Mg2+-ATPase and Ca2+-ATPase activities, play a key role in the early responses induced by the traumatisms. Irreversible-biochemical responses. The mechanical stimulus performed on a Bryonia internode induces an acceleration of: i) enzymatic activities related to the lignification, ii) esterification of phenolic acids in the cell wall. Consequently the lignification process is accelerated. Storage of the information. After being received by the target cells the information can be stored during several days before being expressed. At the level of cotyledonary bud, the first message, previously stored, can be expressed or not by a second treatment. Bidens thus behaves as if it was able to “store” and to “retrieve” morphogenetic messages, using a sort of rudimentary memory. The nuclei of the bud cells of the pricked cotyledon show that these cells, initially in G2 phase, divide and then remain in the G1 phase. In Bryonia, calli derived from young stimulated internodes, keep thigmomorphogenetic characteristics during several weeks. In the last part of this paper the particularity of our plant model which permits a study of the transmission and storage of the message, is underlined. The links between the different steps induced by the stimulus are discussed. Special attention is devoted to second messengers and to the amplification of the message. (shrink)

Abstract A Note to Cogito Les Jones Blackburn College Previous submissions include -Intention, interpretation and literary theory, a first lookWittgenstein and St Augustine A DiscussionAreas of Interest – History of Western Philosophy, Miscellaneous Philosophy, European A Note on Cogito Descartes' brilliance in driving out doubt, and proving the existence of himself as a thinking entity, is well documented. Sartre's critique (or maybe extension) is both apposite and grounded and takes these enquiries on to another level. Let's take a look. 'I (...) think' somehow, for all its power, lacks something. What? Consider what one does when thinking (difficult, but we can try). Implicit in the word 'think', in fact the very essence of the word 'think', is that activity is going on, and if such activity is going on then it must be going on about something, an object, an emotion, a problem,or maybe some dreamlike state, but common to all these is that something is going on. Is that really so? Well, if that wasn't so we would be able to think in a pure state, wouldn't we? But what does a pure state of 'thinking' mean? It can't mean that there isnothing there, because if there were nothing there then no thinking would be taking place. Can it mean that we are thinking of nothing? Well no, because if we are thinking of nothing then we are thinking of something, we are contemplating the notion, or the nature, of nothing. In fact, one can argue that if we talk of something, inthis case nothing or nothingness, then in our head we have some notion of what that is, i.e. something exists in the mind for it to come out of our mouths. Thinking is a recognition of something outside the individual, for the very act of direction, which isan indispensable part of thinking, recognises, must recognise, that there are things to address outside the individual. Something else to bear in mind. According to Sartre human beings are condemned to freedom. Why condemned? Human beings did not choose to be born, but the act ofbeing born also imparts the freedom of which Sartre speaks. Freedom is something which we parrot off as being a sine qua non for the human condition. I believe that's true, but freedom in this sense isn't without its consequences for the individual humanbeing, for individual human beings handle freedom differently. To some it enables them to fly, to others it imparts immense pressures, anguish, heartbreak, unhappiness can all be associated with such freedom. Each individual is responsible for his destiny, for his direction. If someone says that God impelled him, that individual chose his or her God, and chose to obey his or her God. This believer has to sift through the multitude of things that his or her God desire of him or her. All this is fine, so long as we acknowledge what is going on here. Belief in God is, by definition, a belief. Belief, following Wittgenstein, is a language game with its rules and its boundaries. The essential feature of religion as language game are its boundaries, which can be summed up in the word belief. OK, belief has its practises which are its constituent parts, but belief is the boundary between religion and other language games, as the proof constituents are different. Our world is determined by the language used to describe everything that goes on within it. The boundaries of our world are set by the language we use. This might be better put as language gives access to ever expending boundaries. Ever expanding boundaries are only possible by ever expanding thought, and ever expanding thought is only possible by ever expanding directions to our thought brought about through language. It is a fact taken that to be conscious is to think. How could this be otherwise? Consciousness without thought just does not make sense. Imagine a state of consciousness without directional thought. What would it be like? It would be something never experienced, completely out of our understanding. Why? Because understanding itself is a directional thought process. If we say we are going outside our understanding then that is a world of void, and a world of void does not exist. Can such a world be contemplated in our thinking? Well, yes, but then it requires thinking, and thinking requires direction, and such direction requires language. Why does direction require language? Because there is no other way for human beings to articulate a directional thought. Could one point at an image without language? Well, one could have an image in mind, but the essence of saying something about it, of descriptive power, brings us back to the essence, to the power of language to direct. So what of this language of which we speak? Wittgenstein's private language argument points us towards the notion that language itself constantly develops and redevelops through human interaction. Descarte's cogito implies that thinking rules out doubt of one's own existence. But such thinking, to be valid, to make sense, to direct, must develop in a language that has developed, has been verified, by a plurality, by a plurality whose essence is social. Correct use of language symbols, i.e. words, requires that we verify and reverify the accuracy of such symbols. How do we do that? We do that in constant usage, in constant interaction, with other human beings. An individual using a private language could not be understood by others, his symbol system has not been verified by others, his meanings may not be your meanings. It follows from what we have said above that language is constructed, and is continually constructed, in a social context. Given our previous thoughts regarding verification this could not be otherwise. Language has a normative form. All language users are required, by their very use of the language, to verify the use of terms, grammar etc etc. As Wittgenstein cites (appropriately) games as a model, let us take a look. If I play e.g. Ludo, I am governed by the rules. It is not just that I may play dishonestly, for if I were to play at all that very dishonesty, to count as Ludo, would have to be rule governed. The rules of Ludo are Ludo, they are the essence and the constitution of it. Wittgenstein, particularly in his later writings, interweaves many concepts, and connects them in different and sometimes rather elusive ways. Wittgenstein sees concepts like emotions, sentiments and experiences in these interweaving maps. Of course these can be regarded as psychological concepts ** Language can be considered in another but related way, as embodying the elements of a cultural heritage. Language was seen as embodying the notion of higher culture in the arts, architecture etc. Over recent decades this has tended to shift to consider less tangible benefits, such things as oral traditions, cultural values and cultural identity. So language enables us to explore, through the achievements of past generations, cultural mores that may have laid unchallenged for many years. Many of these values and mores may be seen as independent of the language by which they are transmitted, but still this monumental accomplishment of mankind i.e. language, enables man to explore, to modify, to codify, to extend the boundaries of human experience. There are therefore massive implications for our Note on Cogito of Wittgenstein's work. Following Wittgenstein emotions and other psychological concepts can be termed depth grammar, and are distinguished by the fact that the third person of the present is recognised by observation, the first person is not. Taking Wittgenstein's well known pain example the sentence 'He is in pain' is a third person statement of an observational nature. The sentence 'I am in pain' is not derived from observation but from experience, it is an expression of that experience, it's essence is the experience. The asymmetry consists in the fact that predicting psychological attributes of others is warranted by what they do and say. By contrast, the use of such statements in the first person present tense does not rest on one's observation of one's own behaviour. (Hacker 2010:287) p 9 According to Wittgenstein 'I am in pain' is more like a cry of pain, an expression of pain, than a report of some pain. Of course this appertains for other similar statements. 'I feel good' etc. (shrink)

This work of vast erudition, which according to the author is substantially the same as the original Swedish edition, attempts to show how the young Augustine integrated certain key concepts of ancient philosophy into Christian thought. Holte limits himself to the philosophical issues and so does not consider the young Augustine as theologian. Parts I and II develop the historical background of the concept telos in the ancient philosophers and in the early Fathers. Part III presents the central thesis: that (...) Augustine tried to link the contemplative life to the commandment of love which requires total abandonment to God of every form of human life. The Telos is to be found in the contemplative life, although Augustine never separates it from the active. Telos is to be realized in the study of Christian philosophy and scripture. Part IV treats of this realization as a sort of Christian gnosis which can be briefly characterized from the point of view of systematic theology as fides quaerens intellectum.--V. G. P., S.J. (shrink)